Congratulations to Professor Nan-Wei Su laboratory on the publication in a leading journal.
A Versatile Dikinase from Bacillus Opens Greener Path to Water-Soluble Nutraceuticals
A research team led by Professor Nan-Wei Su from the Department of Agricultural Chemistry at National Taiwan University has recently identified a multifunctional dikinase enzyme derived from Bacillus subtilis. This enzyme, named BsPPS (phenolic phosphate synthetase), efficiently attaches phosphate groups to a wide range of natural phenolic compounds. With high substrate selectivity and catalytic efficiency, BsPPS enables phosphorylation of over 30 natural substances, including flavonoids, coumarins, and curcumin.
This innovative technique significantly enhances the water solubility and bioavailability of pharmaceuticals and nutraceuticals. Moreover, it offers a more environmentally friendly and precise alternative to conventional chemical phosphorylation, opening new avenues for the development of prodrugs and functional foods.
The findings have been published in the international journal ACS Catalysis and have garnered attention from multiple scientific media outlets.
