國立臺灣大學 農業化學系

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[演講公告] 111年4月8日(五) Study of RNA virus-host interaction by multi-omics approaches(講者:郭瑞琳教授)

  • 2022-03-08
  • Admin Admin

日期:111年 4 月 8 日 (星期五)

時間:下午1:20~3:10

地點:農化館第五教室

講者:長庚大學醫技系 郭瑞琳教授

演講題目:Study of RNA virus-host interaction by multi-omics approaches

演講大綱:
Infection of emerging or re-emerging RNA viruses, such as influenza A virus and enteroviruses, could result in severe diseases in humans. In the infected cells, the biological processes are altered by either the event of infection or viral protein expression. Influenza A virus is a respiratory virus that could cause pandemics in history. The NS1 protein of influenza A virus antagonizes cellular antiviral response through various mechanisms. To globally study the cellular functions that are affected by the NS1 protein, we applied a proteomic approach to identify host proteins that may associate with the NS1 protein. The results showed that several proteins involved in RNA processing and protein targeting, respectively, could interact with the NS1 protein. In addition to influenza A virus, human enterovirus type A71 (EV-A71) could cause severe neurological complications in children. Therefore, we used a similar approach to investigate the biological impacts of the RNA-dependent RNA polymerase (RdRP, also denoted as 3D protein) encoded by EV-A71 on host cells. Moreover, since viral infection can dysregulate gene expression in host cells, we applied the single-cell RNA sequencing on EV-A71-infected cells to analyze the gene dysregulation at a single-cell level. In summary, we have used proteomics and transcriptomic approaches to study the virus-host interaction that may be impacted on viral replication and pathogenicity.

講者學經歷:
Education:
Year Degree/Institutes
2003 Ph.D., Institute of Microbiology and Immunology, National
Yang-Ming University (陽明大學微生物暨免疫學研究所), Taiwan
1994 M.S., Institute of Microbiology and Immunology, National Yang-Ming
University (陽明大學微生物暨免疫學研究所), Taiwan
1992 B.S., Department of Medical Technology, Taipei Medical College (
北醫學院醫技系), Taiwan
  
Professional experience:
Years Positions
2021-present Professor, Research Center for Emerging Viral Infections & Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taiwan
2016-2021 Associate professor, Research Center for Emerging Viral Infections & Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taiwan
2010-2016 Assistant professor, Research Center for Emerging Viral Infections & Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taiwan
2007-2010 Research Associate, Institute for Cellular and Molecular Biology, University of Texas at Austin, USA
2003-2007 Postdoctoral Fellow, Institute for Cellular and Molecular Biology, University of Texas at Austin, USA